Result card

  • SAF5: Are there susceptible patient groups that are more likely to be harmed through use of FIT?
Fecal Immunochemical Test (FIT ) versus guaiac-based fecal occult blood test (FOBT) for colorectal cancer screening
C0005
English
Guidance Resources

Are there susceptible patient groups that are more likely to be harmed through use of FIT?

Authors: Agnes Männik, Irena Guzina, Petra Jandova, Leonor Varela Lema, Gerardo Atienza Merino

Internal reviewers: Matthias Schwenkglenks, Ingrid Wilbacher

Domain literature search was used.

No susceptible patient goups are known, that would be more likely to be harmed through use of FIT or gFOBT. However there is one study addressing the risk of harm of colonoscopy in patients with co-morbidities.

 

  • Hughes, K., B. Leggett, et al. (2005). "Guaic versus immunochemical tests: faecal occult blood test screening for colorectal cancer in a rural community." {13}

 

Complications related to colonoscopy are increased if participants with major co-morbidity are included in screening and referred for colonoscopy. One such patient of 92 patients, who underwent colonoscopy, developed heart failure during colonoscopy preparation.

No other susceptible patient groups were found from literature, that could be more likely to be harmed through use of FIT or gFOBT. One study suggests, that patients with co-morbidities can more likely to be harmed through use of colonoscopy.

Critical
Completely
Männik A et al. Result Card SAF5 In: Männik A et al. Safety In: Jefferson T, Cerbo M, Vicari N [eds.]. Fecal Immunochemical Test (FIT ) versus guaiac-based fecal occult blood test (FOBT) for colorectal cancer screening [Core HTA], Agenas - Agenzia nazionale per i servizi sanitari regionali; 2014. [cited 17 August 2022]. Available from: http://corehta.info/ViewCover.aspx?id=206

References