Morbidity was assessed by Cosford et al., but the SR did not find any RCTs for outcomes that, for instance, were associated with complications of surgery such as distal embolus, haemorrhage and graft failure, coronary and cerebrovascular events or renal complications (Cosford 2007). However, as this research question is also covered in the Safety domain in SAF1, this is referred to for EFF7.