Result card

  • EFF6: How does Abdominal Aorta Aneurysm Screening modify the progression of the target condition?
Abdominal Aorta Aneurysm Screening
D0006
English
Guidance Resources

How does Abdominal Aorta Aneurysm Screening modify the progression of the target condition?

Authors: Katrine Frønsdal, Stefan Sauerland and Ingvil Sæterdal

Internal reviewers: Pseudo164 Pseudo164, Pseudo179 Pseudo179, Pseudo71 Pseudo71, Pseudo98 Pseudo98

Evidence issued from the basic literature search (done for the whole project) is used to assess this element. Methods for reporting clinical effectiveness data and assessment of strength of evidence are as described in Domain Methodology.

One SR was included to assess the effect of AAA screening on the incidence of ruptured AAA (Cosford 2007). This SR was determined to be of high quality (Appendix EFF-2, Section 2). GRADE Summaries of findings (SoF) tables for this outcome for men and women are shown in Appendix EFF-2 Section 5.

Incidence of ruptured AAA in men

The Cosford et al. SR was the most recent SR assessing the incidence of ruptured AAA in men (Cosford 2007). One RCT included a total of 6,433 men aged between 65 and 80 years randomised to an invitation to attend screening for AAA (n=3,205) or no invitation (control; n=3,228). The ORs showed a significant reduction in the incidence of ruptured AAA in the screened group (see SoF table in Appendix EFF-2 Section 5). The random-effect OR was 0.45 with a 95% CI of 0.21 to 0.99, P=0.048.

Incidence of ruptured AAA in women

The Cosford et al. SR was the most recent SR assessing incidence of ruptured AAA in women (Cosford 2007). One RCT included in total 9,342 women aged between 65 and 80 years randomised to an invitation to attend screening for AAA (n=4,682) or no invitation (control; n=4,660). The odds ratio (ORs) showed a non-significant increase in the incidence of ruptured AAA in the screened group (see SoF table in Appendix EFF-2 Section 5). The random-effect OR was 1.49 with a 95% CI of 0.25 to 8.94, P=0.66.

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Completely
Frønsdal K, Sæterdal S Result Card EFF6 In: Frønsdal K, Sæterdal S Clinical Effectiveness In: Jefferson T, Vicari N, Frønsdal K [eds.]. Abdominal Aorta Aneurysm Screening [Core HTA], Agenzia nationale per i servizi sanitari regionali (age.na.s), Italy; 2013. [cited 28 May 2023]. Available from: http://corehta.info/ViewCover.aspx?id=106