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  • CUR4: What is the natural course of AAA?
  • CUR22: What is the natural course of ruptured AAAs Jump to
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What is the natural course of AAA?

Authors: Pseudo218 Pseudo218, Pseudo73 Pseudo73

Internal reviewers: Paolo Giorgi Rossi, Lotte Groth Jensen

In its natural course, an AAA is typically symptom free to begin with. The arterial dilatation takes place gradually over the years and is diagnosed as AAA when the arterial diameter reaches 3 cm (Different definitions are used for men and women because the vessels of women are on average smaller than those of men.). Over time the diameter usually increases at a rate that depends on the diameter. In small aneurysms it increases by about 2 mm per year, but in large aneurysms it grows by about 3.5 mm per year. In smokers the rate of increase can be higher. The rate of growth can vary, with phases of no growth and phases of rapid growth{Mohler, Natural ...}. AAAs can be symptomless during the whole life or until rupture. Alternatively symptoms may be present (see A0005).

The pathogenic roles of an inflammatory process (matrix metalloproteinase) and pathological coagulation (plasmin generation) have recently been described {3}. These processes damage the vessel wall, which becomes more vulnerable to the pulsating blood pressure leading to increased dilatation and finally to rupture.

Of the patients with a ruptured AAA, 50% reach hospital alive. Among those who reach hospital alive and have an operation, 50% survive the repair.

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Pseudo218 P, Pseudo73 P Result Card CUR4 In: Pseudo218 P, Pseudo73 P Health Problem and Current Use of the Technology In: Jefferson T, Vicari N, Frønsdal K [eds.]. Abdominal Aorta Aneurysm Screening [Core HTA], Agenzia nationale per i servizi sanitari regionali (age.na.s), Italy; 2013. [cited 28 May 2023]. Available from: http://corehta.info/ViewCover.aspx?id=106

What is the natural course of ruptured AAAs

Authors: Pseudo218 Pseudo218, Pseudo73 Pseudo73

Internal reviewers: Paolo Giorgi Rossi, Lotte Groth Jensen

See CUR4

Pseudo218 P, Pseudo73 P Result Card CUR22 In: Pseudo218 P, Pseudo73 P Health Problem and Current Use of the Technology In: Jefferson T, Vicari N, Frønsdal K [eds.]. Abdominal Aorta Aneurysm Screening [Core HTA], Agenzia nationale per i servizi sanitari regionali (age.na.s), Italy; 2013. [cited 28 May 2023]. Available from: http://corehta.info/ViewCover.aspx?id=106

References