All relevant conditions and populations should be included. This question is especially relevant when there are multiple potential target conditions and populations for which the technology is used, and multiple intended uses, both indicated and other. There may also be differing views about the appropriate use of the technology that it is essential to highlight. Describe the differences in the use of the technology for the various indications and how it might act differently in different patient groups. Point out e.g. if certain populations should be excluded from using the technology, or if they require e.g. a different dosage. Certain technologies may be primarily indicated for second-line use but also used for first-line treatment.

Sources: HTAs, guidelines, reviews, clinician consultation, developers/manufacturers.

Method: A descriptive summary.

Burls 2000 {1}, Busse 2002 {2}, Liberati 1997 {3}, Imaz-Iglesia 1999, Kristensen 2007 {24}